Malignant melanoma classification given additional genetic component


Malignant melanoma classification given additional genetic component


Existing melanoma classifications have been refined by a team at the University of California San Francisco according to an article released on June 2, 2008 in the open access journal PLoS Medicine.

Melanoma, a malignant tumor of melanocytes, are presently classified by morphological means. The present classification system, while generally consistent, does not offer information about the treatment methods that are best suited to that cancer. This team refined these morphological systems by their causative mutations, creating genetically homogeneous subgroups. This holds promise to help patients whose tumors have metastisized find better treatment options.

Jonathan Rees of the University of Edinburgh contributed a related Research in Translation paper, in which he highlights several omissions in our knowledge about the etiology of non-acral melanomas.

Improving melanoma classification by integrating genetic and morphologic features.

Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, et al.

PLoS Med 5(6): e120.

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Melanoma: What are the gaps in our knowledge?

Rees JL

PLoS Med 5(6): e122.

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Malignant Melanoma – Symptoms and Causes of the Final Stage Skin Cancer (Video Medical And Professional 2018).

Section Issues On Medicine: Disease